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These free radicals can directly attack polyunsaturated fatty acids (such as arachidonic acid AA and adrenal acid AdA) in the cell membrane, trigger lipid peroxidation, accelerate the occurrence of lipid peroxidation, produce a large number of reactive oxygen species (ROS), and then promote ferroptosis ( ) pathway, glutathione peroxidase 4 (GPX4) pathway, inhibitor of ferroptosis protein 1-Coenzyme Q10 (FSP1-CoQ10) pathway and P53 pathway (Zheng and Conrad, 2020

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Gasdermin D-deficient mice are hypersensitive to acute kidney injury

Less inflammation means less pain, quicker healing, and stronger, healthier tissues